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Fractyl Health Surges Amid Positive Trial Results and Strategic Developments

Matt MonacoAvatar
Written by Matt Monaco
Updated 9/27/2025, 9:13 am ET | 6 min

In this article Last trade Sep, 26 7:44 PM

  • GUTS+33.66%
    GUTS - NYSEFractyl Health, Inc.
    $1.35+0.34 (+33.66%)
    Volume:  74.87M
    Float:  31.08M
    $1.00Day Low/High$1.40

Stocks of Fractyl Health, Inc. have been trading up by 34.65% due to promising new FDA developments.

Healthcare industry expert:

Analyst sentiment – neutral

Market Position & Fundamentals: Analysis of GUTS indicates a challenging market position characterized by negative profitability metrics and weak financial fundamentals. A gross margin of 58.8% is starkly overshadowed by concerning signs such as a negative price-to-book ratio of -2.79 and a return on assets at -58.56%. Revenue stands at 93,000, but profitability is severely strained with EBIT and EBITDA both reflecting significant losses. The current ratio of 1.2 implies adequate short-term liquidity, yet the outlook is dampened by a high long-term debt burden indicated by a long-term debt to capital ratio of 1.47. The company’s cash flow statement highlights negative free cash flow of -21.3 million, further underscoring operational difficulties.

Technical Analysis & Trading Strategy: GUTS’ weekly price analysis exhibits a bullish trend with notable upward movement from a close of 1.0198 on 250925 to a significant closing high of 1.36 on 250926. The sharp increase in price from 0.9917 to 1.36 within a trading week marks a robust bullish momentum. Key support is identified at 1.00, with resistance forming around 1.40. Volume analysis supports the upward trend, suggesting sustained buying interest. For traders, a long position strategy is advised, entering at support at 1.00 and targeting the resistance level, leveraging stop-loss orders below the support level.

Catalysts & Outlook: Recent developments like Ladenburg and H.C. Wainwright’s Buy ratings suggest confidence in GUTS’ emerging strategies in obesity treatment, backed by positive interim results from the REMAIN-1 study. These catalysts indicate potential for future growth, particularly with the Revita therapy showing promise in maintaining weight loss. However, the lowered price target to $8 reflects caution over current equity adjustments. Compared to broader industry benchmarks, GUTS’ innovative approach is promising, but financial and operational hurdles persist. The technical outlook is positive within a speculative context, with potential upward momentum toward a revised price target of $3.60 aligning with Ladenburg’s valuation.

  • Interim results from the REMAIN-1 study highlight Revita’s potential in maintaining weight loss after GLP-1 drug therapy, boosting Fractyl’s stock performance with reports of significant additional weight loss from patients.

  • The company’s $60M share offering announcement at $1 per share has driven the stock up significantly, showcasing market confidence in Fractyl Health’s future direction.

  • Positive trial outcomes for Revita, indicating continued weight loss post-drug therapy cessation, are portrayed as highly promising, supporting share price increases.

  • Strategic additions to the Board of Directors with veterans Christopher Thompson and Ian Sheffield are seen as pivotal for future growth, reinforcing Fractyl Health’s roadmap in advancing Revita and Rejuva.

Candlestick Chart

Weekly Update Sep 22 – Sep 26, 2025: On Saturday, September 27, 2025 Fractyl Health, Inc. stock [NASDAQ: GUTS] is trending up by 34.65%! Discover the key drivers behind this movement as well as our expert analysis in the detailed breakdown below.

Quick Financial Overview

Fractyl Health’s recent financial metrics suggest an organization with significant revenue potential, but still navigating financial strength challenges. The stock’s performance exhibited noteworthy volatility over recent days. The rapid ascent in share price after the share offering reflects active investor enthusiasm and speculative interest in Fractyl’s drug therapies and their potential market impact.

From a broader financial perspective, the company’s high price-to-sales ratio, coupled with negative earnings and free cash flow metrics, underscores both its growth orientation and related risk exposure. Despite these challenges, Fractyl’s robust gross margin and a reasonably balanced current ratio indicate some cushion against short-term liabilities. However, the firm’s tangible book value poses questions for long-term financial sustainability.

More Breaking News

The data suggests a company still in its growth phase, leveraging its promising trial results to bolster investor confidence. As seen in the trading activity, larger strategic moves and ongoing research have the potential to greatly impact Fractyl’s valuation. Understanding market dynamics and investor reactions will be crucial for stakeholders going forward.

Conclusion: Optimism Accompanied by Caution

Investors are bullish on Fractyl Health as recent developments indicate promising avenues for its core treatments. The stock’s response to trial data and strategic maneuvers speaks volumes about market perception and trader sentiment. Though challenges regarding financial sustainability remain, the overall trajectory is one of optimism tethered to strategic prudence and clinical progress.

While assessing Fractyl Health, it’s crucial to remember that in trading, as millionaire penny stock trader and teacher Tim Sykes, says, “There is always another play around the corner; don’t chase just because you feel FOMO.” As Fractyl Health traverses the ever-dynamic biopharmaceutical landscape, the upcoming years will be pivotal. High-caliber board appointments and resourceful capital engagement strategies bolster the foundation for an exciting phase of growth. Navigating these opportunities with calculated risk assessment will be essential in harnessing the full potential of Fractyl’s novel therapies.

This is stock news, not investment advice. Timothy Sykes News delivers real-time stock market news focused on key catalysts driving short-term price movements. Our content is tailored for active traders and investors seeking to capitalize on rapid price fluctuations, particularly in volatile sectors like penny stocks. Readers come to us for detailed coverage on earnings reports, mergers, FDA approvals, new contracts, and unusual trading volumes that can trigger significant short-term price action. Some users utilize our news to explain sudden stock movements, while others rely on it for diligent research into potential investment opportunities.

Dive deeper into the world of trading with Timothy Sykes, renowned for his expertise in penny stocks. Explore his top picks and discover the strategies that have propelled him to success with these articles:

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Matt Monaco

Mentor and Trainer at StocksToTrade.com, Lead Mentor at Small Cap Rockets and To The Moon Report
He is a diligent trader and teacher in his To The Moon Report blogs and Small Cap Rockets strategy webinars. He shows up every day, and expects his students to as well. Matt is fond of trading sketchy, volatile OTC stocks with profit potential. His favorite patterns are panic dip buys and breakouts.
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* Results are not typical and will vary from person to person. Making money trading stocks takes time, dedication, and hard work. There are inherent risks involved with investing in the stock market, including the loss of your investment. Past performance in the market is not indicative of future results. Any investment is at your own risk. See Terms of Service here

The available research on day trading suggests that most active traders lose money. Fees and overtrading are major contributors to these losses.

A 2000 study called “Trading is Hazardous to Your Wealth: The Common Stock Investment Performance of Individual Investors” evaluated 66,465 U.S. households that held stocks from 1991 to 1996. The households that traded most averaged an 11.4% annual return during a period where the overall market gained 17.9%. These lower returns were attributed to overconfidence.

A 2014 paper (revised 2019) titled “Learning Fast or Slow?” analyzed the complete transaction history of the Taiwan Stock Exchange between 1992 and 2006. It looked at the ongoing performance of day traders in this sample, and found that 97% of day traders can expect to lose money from trading, and more than 90% of all day trading volume can be traced to investors who predictably lose money. Additionally, it tied the behavior of gamblers and drivers who get more speeding tickets to overtrading, and cited studies showing that legalized gambling has an inverse effect on trading volume.

A 2019 research study (revised 2020) called “Day Trading for a Living?” observed 19,646 Brazilian futures contract traders who started day trading from 2013 to 2015, and recorded two years of their trading activity. The study authors found that 97% of traders with more than 300 days actively trading lost money, and only 1.1% earned more than the Brazilian minimum wage ($16 USD per day). They hypothesized that the greater returns shown in previous studies did not differentiate between frequent day traders and those who traded rarely, and that more frequent trading activity decreases the chance of profitability.

These studies show the wide variance of the available data on day trading profitability. One thing that seems clear from the research is that most day traders lose money .

Millionaire Media 66 W Flagler St. Ste. 900 Miami, FL 33130 United States (888) 878-3621 This is for information purposes only as Millionaire Media LLC nor Timothy Sykes is registered as a securities broker-dealer or an investment adviser. No information herein is intended as securities brokerage, investment, tax, accounting or legal advice, as an offer or solicitation of an offer to sell or buy, or as an endorsement, recommendation or sponsorship of any company, security or fund. Millionaire Media LLC and Timothy Sykes cannot and does not assess, verify or guarantee the adequacy, accuracy or completeness of any information, the suitability or profitability of any particular investment, or the potential value of any investment or informational source. The reader bears responsibility for his/her own investment research and decisions, should seek the advice of a qualified securities professional before making any investment, and investigate and fully understand any and all risks before investing. Millionaire Media LLC and Timothy Sykes in no way warrants the solvency, financial condition, or investment advisability of any of the securities mentioned in communications or websites. In addition, Millionaire Media LLC and Timothy Sykes accepts no liability whatsoever for any direct or consequential loss arising from any use of this information. This information is not intended to be used as the sole basis of any investment decision, nor should it be construed as advice designed to meet the investment needs of any particular investor. Past performance is not necessarily indicative of future returns.

Citations for Disclaimer

Barber, Brad M. and Odean, Terrance, Trading is Hazardous to Your Wealth: The Common Stock Investment Performance of Individual Investors. Available at SSRN: “Day Trading for a Living?”

Barber, Brad M. and Lee, Yi-Tsung and Liu, Yu-Jane and Odean, Terrance and Zhang, Ke, Learning Fast or Slow? (May 28, 2019). Forthcoming: Review of Asset Pricing Studies, Available at SSRN: “https://ssrn.com/abstract=2535636”

Chague, Fernando and De-Losso, Rodrigo and Giovannetti, Bruno, Day Trading for a Living? (June 11, 2020). Available at SSRN: “https://ssrn.com/abstract=3423101”

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