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Arrowhead’s Plozasiran Garners FDA Breakthrough Recognition

Bryce TuoheyAvatar
Written by Bryce Tuohey
Updated 12/8/2025, 11:33 am ET | 5 min

In this article Last trade Dec, 08 12:53 PM

  • ARWR+13.22%
    ARWR - NYSEArrowhead Pharmaceuticals Inc.
    $69.56+8.12 (+13.22%)
    Volume:  2.89M
    Float:  129.97M
    $61.99Day Low/High$71.50

Arrowhead Pharmaceuticals Inc. stocks have been trading up by 15.33 percent after new FDA approvals fueled market optimism.

Candlestick Chart

Live Update At 11:33:01 EST: On Monday, December 08, 2025 Arrowhead Pharmaceuticals Inc. stock [NASDAQ: ARWR] is trending up by 15.33%! Discover the key drivers behind this movement as well as our expert analysis in the detailed breakdown below.

Quick Financial Overview

Arrowhead Pharmaceuticals has captured the market’s attention with stunning financial achievements reported at the close of their fiscal year 2025. The company announced a substantial rise in revenue, reaching around $829.4M, a significant leap from previous records. Not only did the revenue climb, but Arrowhead also pivoted from a loss last year to net a $30.1M profit, buoyed by their strategic advancements and pipeline successes.

The surge in revenue, alongside FDA approvals and collaborations, has led to a notable boost in investor confidence. Stock prices soared due to these positive developments, reflecting market optimism about the company’s future trajectory. Breakthroughs like FDA’s approval for their siRNA medicines showcase the potential in their innovative TRiM(TM) platform. All these factors combined have led financial institutions to reevaluate their price targets, with significant increases bolstering Arrowhead’s market valuation.

Trading Insights: After analyzing recent data, it’s apparent the stock saw significant volatility and an upward trajectory. For instance, on Dec 8, 2025, the stock opened at $68.16, eventually touching a high of $71 before closing at $70.81. Such price movements indicate an active market response to Arrowhead’s announcements. Beyond daily highs and lows, the stock’s ability to maintain upward momentum in an increasingly competitive market adds a layer of intrigue for investors tracking biopharmaceutical stocks with promising therapeutic offerings.

Momentum from Milestone Achievements

Throughout November, Arrowhead Pharmaceuticals marked several milestones that not only captivated market attention but also underlined their innovative edge. A notable event was the FDA’s Breakthrough Therapy designation for Plozasiran, a groundbreaking drug aimed at addressing severe hypertriglyceridemia. This endorsement not only validates the drug’s potential but also sets the stage for an accelerated review process, potentially propelling it to market faster than anticipated.

The announcement of significant revenue uplift paired with a reversal to profitability paints a vivid picture of a company on the rise. A noteworthy collaboration with Novartis further amplifies their strategic approach, suggesting a broadened impact in the pharmaceutical landscape.

Adding to these dynamics, Arrowhead has successfully secured a $200M milestone payment from Sarepta Therapeutics. This is tied to their progress in the clinical development of ARO-DM1, which aims to tackle type 1 myotonic dystrophy, a condition that presents limited treatment avenues. Such achievements underscore the versatility and applicability of Arrowhead’s RNAi-based solutions.

More Breaking News

Considering financial metrics, Arrowhead’s gross margin stands out at a full 100%, illustrating robust product profitability. While a pre-tax profit margin of -74.3% indicates challenges, overall profitability has been bolstered by a net profit margin at 3.63%.

Eternal Optimism and Market Reactions

The enthusiasm around Arrowhead’s FDA-approved products and strategic partnerships has stimulated a palpable shift in market sentiments. Financial analysts have revised adjusted price targets upwards, mirroring the growing investor confidence anchored in Arrowhead’s transformative fiscal outcomes. Not just the qualitative advancements but quantitative financial health fortifies the market’s optimism with tangible metrics.

The recent upswing in stock price, as much as 25% in response to robust year-end announcements, restates the effectivity of Arrowhead’s strategic trajectory. Cross-referencing fiscal data, the enterprise value has surpassed $8B while the total assets value $1.38B employs an efficient capital turnover given a total revenue close to historically high benchmarks.

Conclusion

In closing, Arrowhead Pharmaceuticals stands poised at a significant juncture. With transformative achievements like FDA Breakthrough Therapy recognitions and lucrative collaborations, the company is enthroned as a substantial contributor to medical innovation. Fiscal gains echo this sentiment, reinforcing the narrative of growth and strategic execution. As millionaire penny stock trader and teacher Tim Sykes, says, “Small gains add up over time; focus on building wealth gradually, not chasing jackpots.” This philosophy is mirrored in Arrowhead’s approach, highlighting the value of steady progress. As the company navigates future challenges and possibilities, market actors pay keen attention, cognizant of the promises embedded in Arrowhead’s expanding RNAi pipeline and entrepreneurial prowess. These developments not only translate into current market vigor but fortify its enduring appeal among traders eyeing biopharmaceutical landmarks.

This is stock news, not investment advice. Timothy Sykes News delivers real-time stock market news focused on key catalysts driving short-term price movements. Our content is tailored for active traders and investors seeking to capitalize on rapid price fluctuations, particularly in volatile sectors like penny stocks. Readers come to us for detailed coverage on earnings reports, mergers, FDA approvals, new contracts, and unusual trading volumes that can trigger significant short-term price action. Some users utilize our news to explain sudden stock movements, while others rely on it for diligent research into potential investment opportunities.

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Bryce Tuohey

Mentor and Trainer at StocksToTrade.com, Lead Mentor at Small Cap Rockets and To The Moon Report
Bryce’s first pattern was buying into strength in breakouts. But he noticed when they didn’t work, he took bigger losses. When the OTC market got hot, Bryce learned to dip buy the inevitable panics. He adapted his breakout strategy and now buys consolidation and trend breaks. His goal is to have better risk/reward and get an entry before multi-day listed breakouts.
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In this article (YTD Performance)


* Results are not typical and will vary from person to person. Making money trading stocks takes time, dedication, and hard work. There are inherent risks involved with investing in the stock market, including the loss of your investment. Past performance in the market is not indicative of future results. Any investment is at your own risk. See Terms of Service here

The available research on day trading suggests that most active traders lose money. Fees and overtrading are major contributors to these losses.

A 2000 study called “Trading is Hazardous to Your Wealth: The Common Stock Investment Performance of Individual Investors” evaluated 66,465 U.S. households that held stocks from 1991 to 1996. The households that traded most averaged an 11.4% annual return during a period where the overall market gained 17.9%. These lower returns were attributed to overconfidence.

A 2014 paper (revised 2019) titled “Learning Fast or Slow?” analyzed the complete transaction history of the Taiwan Stock Exchange between 1992 and 2006. It looked at the ongoing performance of day traders in this sample, and found that 97% of day traders can expect to lose money from trading, and more than 90% of all day trading volume can be traced to investors who predictably lose money. Additionally, it tied the behavior of gamblers and drivers who get more speeding tickets to overtrading, and cited studies showing that legalized gambling has an inverse effect on trading volume.

A 2019 research study (revised 2020) called “Day Trading for a Living?” observed 19,646 Brazilian futures contract traders who started day trading from 2013 to 2015, and recorded two years of their trading activity. The study authors found that 97% of traders with more than 300 days actively trading lost money, and only 1.1% earned more than the Brazilian minimum wage ($16 USD per day). They hypothesized that the greater returns shown in previous studies did not differentiate between frequent day traders and those who traded rarely, and that more frequent trading activity decreases the chance of profitability.

These studies show the wide variance of the available data on day trading profitability. One thing that seems clear from the research is that most day traders lose money .

Millionaire Media 66 W Flagler St. Ste. 900 Miami, FL 33130 United States (888) 878-3621 This is for information purposes only as Millionaire Media LLC nor Timothy Sykes is registered as a securities broker-dealer or an investment adviser. No information herein is intended as securities brokerage, investment, tax, accounting or legal advice, as an offer or solicitation of an offer to sell or buy, or as an endorsement, recommendation or sponsorship of any company, security or fund. Millionaire Media LLC and Timothy Sykes cannot and does not assess, verify or guarantee the adequacy, accuracy or completeness of any information, the suitability or profitability of any particular investment, or the potential value of any investment or informational source. The reader bears responsibility for his/her own investment research and decisions, should seek the advice of a qualified securities professional before making any investment, and investigate and fully understand any and all risks before investing. Millionaire Media LLC and Timothy Sykes in no way warrants the solvency, financial condition, or investment advisability of any of the securities mentioned in communications or websites. In addition, Millionaire Media LLC and Timothy Sykes accepts no liability whatsoever for any direct or consequential loss arising from any use of this information. This information is not intended to be used as the sole basis of any investment decision, nor should it be construed as advice designed to meet the investment needs of any particular investor. Past performance is not necessarily indicative of future returns.

Citations for Disclaimer

Barber, Brad M. and Odean, Terrance, Trading is Hazardous to Your Wealth: The Common Stock Investment Performance of Individual Investors. Available at SSRN: “Day Trading for a Living?”

Barber, Brad M. and Lee, Yi-Tsung and Liu, Yu-Jane and Odean, Terrance and Zhang, Ke, Learning Fast or Slow? (May 28, 2019). Forthcoming: Review of Asset Pricing Studies, Available at SSRN: “https://ssrn.com/abstract=2535636”

Chague, Fernando and De-Losso, Rodrigo and Giovannetti, Bruno, Day Trading for a Living? (June 11, 2020). Available at SSRN: “https://ssrn.com/abstract=3423101”

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